Key Aspects Of The Safe Use Of Nonsteroidal Anti-Inflammatory Drugs In Children

Abstract

Nonsteroidal anti-inflammatory drugs (NSAIDs) occupy an important place in pediatric practice due to their pronounced analgesic, antipyretic, and anti-inflammatory effects. However, their use in children requires particular caution due to age-related differences in pharmacokinetics and pharmacodynamics, immature detoxification systems, and increased sensitivity to side effects. The aim of this article is to comprehensively analyze key aspects of the safe use of NSAIDs in children, including indications, dosage, potential risks, drug interactions, and current approaches to minimizing adverse reactions. This paper summarizes clinical observation data, the results of modern research, and international guidelines, allowing for the formulation of practical conclusions for clinicians. Particular attention is paid to issues of gastrointestinal, nephrotoxic, and cardiovascular safety, as well as the rational choice of drug based on age and clinical situation.