Nanostructured Serums and Device-Based Methods for Nanoparticle Delivery: An Innovative Alternative to Injection Therapy for Acne
Keywords:
Acne, nanotechnologies, nanostructured serums, hardware cosmetology, noninvasive delivery, liposomes, sonophoresis, photobiomodulation (LED), laser-assisted delivery (LADD), intralesional injectionsAbstract
Acne remains a global dermatological problem, the burden of which continues to grow. Traditional treatment methods for severe forms, in particular intralesional injections (ILK), are associated with significant risks, including irreversible skin atrophy. The aim of this study is a systematic analysis and theoretical justification of protocols that combine nanostructured serums (NSS) and apparatus-based delivery methods (ADM) as an innovative noninvasive alternative. The methodology is based on a systematic review of academic and industry sources, including a comparative analysis of clinical data. The results show that NSS (for example, liposomal tretinoin) demonstrates 1.5-fold higher efficacy in comedone reduction (94.17% vs 62.36%) and significantly better tolerability compared to conventional gels. Device-based methods, including sonophoresis and LADD, show efficacy (80-89% improvement) comparable to injections. Synergistic protocols (LED photobiomodulation + nano-gel) have clinically demonstrated the ability to significantly reduce the number of papules (-61.58%), sebum level, and erythema. In conclusion, it is noted that the integration of NSS and ADM represents a clinically substantiated, safe, and highly effective alternative to invasive therapy. The findings will be of interest to dermatologists, cosmetologist-estheticians, and researchers in the field of pharmaceutical delivery.
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