Features Of Orthostatic Hypotension In Elderly Patients With Chemical Medication
Keywords:
Chronic cerebral ischemia, elderly patients, orthostatic hypotensionAbstract
Chronic cerebral ischemia (CCI) is one of the most common neurological conditions in elderly patients and has a significant negative impact on functional status and quality of life. Progression of CCI is associated with cognitive decline, impaired postural control, reduced physical activity, and an increased risk of falls, largely due to vascular disorders and autonomic dysfunction. One of the key manifestations of autonomic impairment in this population is orthostatic hypotension, which contributes to statodynamic instability and traumatic complications.
The aim of this study was to identify the clinical features and pathogenetic mechanisms of orthostatic hypotension in elderly patients with different stages of chronic cerebral ischemia in order to optimize diagnostic approaches and develop individualized strategies for treatment and prevention.
The study included 147 elderly patients aged 60–89 years diagnosed with chronic cerebral ischemia and hospitalized in the neurological department of Andijan State Medical Institute between 2019 and 2022. Patients were divided into three groups according to the stage of CCI. A control group consisted of relatively healthy individuals. Clinical assessment included evaluation of postural stability using the Romberg and Unterberger tests, measurement of arterial blood pressure and heart rate in horizontal and vertical positions (orthostatic test), and statistical analysis.
The results demonstrated a progressive increase in the severity and frequency of autonomic disturbances with advancing stages of CCI. Patients with early-stage CCI exhibited mild autonomic symptoms, whereas those with advanced stages showed pronounced orthostatic hypotension, cardiac rhythm disturbances, thermoregulation disorders, and frequent syncopal episodes. These findings indicate a strong association between the progression of chronic cerebral ischemia and the severity of orthostatic hypotension, emphasizing the importance of early diagnosis and targeted management in elderly patients.
References
Benedikt R.A., Kryukov A.N., Kulikova I.V. Diagnosis and treatment of chronic cerebral ischemia: modern approaches // Neurology and neurosurgery. - 2021. - Vol. 10, No. 2. - Pp. 15-22.
Vasiliev P.P., Lebedev A.N., Sukhova E.S. Evaluation of statodynamic disorders in elderly patients with cerebrovascular diseases // Journal of Clinical Neurology. - 2020. - Vol. 8, No. 3. - Pp. 34-39.
Gusev E.I., Skvortsova V.I., Schmidt E.V. Chronic cerebral ischemia: epidemiology, pathogenesis, diagnosis and treatment // Russian Medical Journal. - 2019. - No. 4. – P. 7–15.
Zakharova N.M., Koroleva O.V. Orthostatic hypotension in elderly patients with chronic cerebral ischemia: clinical and functional aspects // Cardiology. – 2022. – Vol. 16, No. 1. – P. 22–29.
Ovchinnikova L.V., Mironova N.A. Balance disorders and risk of falls in elderly patients with chronic neurological diseases // Journal of Rehabilitation. – 2021. – Vol. 9, No. 2. – P. 18–24.
Jameson J.L., Fauci A.S., Kasper D.L. Harrison's Principles of Internal Medicine. 20th ed. – New York: McGraw-Hill Education, 2018. – 2985 p.
Shephard R.J. Aging and Physical Activity. – Champaign: Human Kinetics, 2019. – 456 p.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 J.A. Nazarova, R.M. Abdujamilova, N.U. Mirzakhmedova, Sh.M. Kabilov
This work is licensed under a Creative Commons Attribution 4.0 International License.
