Prospects for the Use of Carboxytherapy in Comprehensive Care for Problematic Skin

Abstract

This article presents a comprehensive analysis of the prospects for applying non-injection carboxytherapy within integrated care programs for problematic skin, taking into account contemporary demands for efficacy, safety, and physiological compatibility of interventions. The study is grounded in an interdisciplinary framework combining clinical dermatology, cosmetology, skin physiology, and evidence-based medicine. Special attention is paid to secondary analysis of scientific literature describing the effects of transdermal and topical CO₂ application on vascular, pigmentary, and structural skin parameters in patients with acne, post-acne, striae, hyperpigmentation, and early cellulite. Both visual-instrumental and clinical outcomes are examined—including skin hydration, elasticity, microcirculation, lymphatic drainage, and patient satisfaction. Findings indicate that noninvasive CO₂ modalities—such as gel formulations, masks, and device-assisted transdermal delivery—produce significant clinical improvements, particularly in the periorbital area and regions with compromised turgor, while maintaining a high safety profile and requiring no recovery time. A comparative review with alternative approaches (PRP, fractional CO₂ laser, IPL) highlights the superior tolerability and multifunctional benefits of noninvasive carboxytherapy, especially for patients with sensitive or thin skin. Limitations of the current evidence base are also identified: variability in treatment protocols, short observation periods, and the lack of standardized efficacy scales. The necessity for methodological standardization and an increase in randomized controlled trials is substantiated. This article will be of value to specialists in aesthetic medicine, clinical dermatologists, skin physiology researchers, and developers of personalized, multitargeted skincare regimens.