Tests for Determining the Analgesic Activity Of 1-Phenylisoquinoline Derivatives
Keywords:
Hot plate, Acetic acid twitching,Abstract
In modern medicine, painkillers are widely used in the treatment of diseases and complications of some diseases. According to the World Health Organization, about 30 million people worldwide use painkillers per day. For example, in Malaysia, the consumption of NSAID is 14.2%, of which 4.2% is considered daily consumption. In Iran, it is 14.7% among 35-70-year-olds, and in Saudi Arabia this figure is 14.0%.
References
Mironov A.N. Guidelines for conducting preclinical studies of medicinal products. Part one. Moscow: Grif i K, 2012. - 944 p
Instructions for Preclinical Safety Testing of Pharmacological Agents" approved by the Ministry of Health of the Republic of Uzbekistan on December 22, 2000
Miskinova F.X., Tursunxodjaeva F.M. Local anesthetic, analgesic activity and toxicity of 1-(4̓-methoxyphenyl)-2B-hydroxyethyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride. Infection, immunity and pharmacology. 2022, No. 3. pp. 171-175.
Guide to experimental (preclinical) study of new pharmacological substances / edited by R.U. Khabriev. - 2nd edition, revised and enlarged. - Moscow: OJSC "Izdatelstvo" Medicine ", 2005. - 832 p
Miskinova F.X., Azamatov A.A., Shukurlaev K.Sh., Tursunxodjaeva F.M. Acute toxicity and analgesic activity of some 1,2,3,4-tetrahydroisoquinoline derivatives in the acetyline writhing test. Infection, immunity and pharmacology. 2023, no. 4. pp. 82-86.
Miskinova F.X., Shukurlaev K.Sh. Analgesic and anti-inflammatory activity of N-derivatives of cytisine and 1-phenylisoquinoline. Infection, immunity and pharmacology. 2025, No. 1. p. 96-100.
IBM SPSS Statistics 27 Documentation. https://www.ibm.com/support/pages/ibm-spss-statistics-27-documentation
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 Miskinova Fazilat Xudayorovna

This work is licensed under a Creative Commons Attribution 4.0 International License.