Neurogenic Mechanisms, Takotsubo Syndrome, And Prevention of Stress-Induced Cardiovascular Diseases
Keywords:
Stress, catecholamines, Takotsubo syndromeAbstract
This article systematizes the neurogenic and psychophysiological mechanisms of stress-induced cardiovascular diseases, including Takotsubo syndrome, as well as psychological risk factors and preventive directions. It shows that catecholamine release, inflammation, endothelial dysfunction, personality traits, and a lack of social support form a unified pathogenetic framework that should be addressed by psychocardiological and rehabilitation interventions.
References
Белялов Ф. И., Вельтищев Д. Ю., Волель Б. А., Гарганеева Н. П., Копылов Ф. Ю., Ларева Н. В. и др. Психические расстройства у пациентов с сердечно-сосудистыми заболеваниями. Консенсус рабочих групп Российского кардиологического общества и Российского общества психиатров // Кардиология. 2025. Т. 65, № 6. С. 54–73. https://therapy.irkutsk.ru/ispm/psomatic_card2c11.pdf
McKenzie A., Bargout R. Takotsubo Syndrome in 2025: Evolving Concepts in Pathophysiology, Diagnosis, and Long-Term Management // Journal of Clinical Medicine. 2026. Vol. 15, No. 1. Art. 197. https://www.researchgate.net/publication/399138036_Takotsubo_Syndrome_in_2025_Evolving_Concepts_in_Pathophysiology_Diagnosis_and_Long-Term_Management
Bacca C. F., Stephan B., Gomez V., Gioli-Pereira L. и др. Use of beta-blockers and in-hospital mortality in patients with Takotsubo cardiomyopathy: systematic review and meta-analysis // Open Heart. 2025. Vol. 12, No. 2. e003762. https://pmc.ncbi.nlm.nih.gov/articles/PMC12581082/
Larionov K., Petrova E., Demirbuga N., Werth O., Breitner M. H., Gebhardt P., Caldarone F., Duncker D., Westhoff-Bleck M., Sensenhauser A., Maxrath N., Marschollek M., Kahl K. G., Heitland I. Improving mental well-being in psychocardiology—a feasibility trial for a non-blended web application as a brief metacognitive-based intervention in cardiovascular disease patients // Frontiers in Psychiatry. 2023. Vol. 14. Art. 1138475. https://pmc.ncbi.nlm.nih.gov/articles/PMC10568139/
Bueno H., Deaton C., Farrero M., Forsyth F., Braunschweig F., Buccheri S. и др. 2025 ESC Clinical Consensus Statement on mental health and cardiovascular disease: developed under the auspices of the ESC Clinical Practice Guidelines Committee // European Heart Journal. 2025. Vol. 46, No. 41. P. 4156–4225. https://www.escardio.org/guidelines/clinical-practice-guidelines/all-esc-practice-guidelines/mental-health-and-cvd/
Ghadri J.-R., Wittstein I. S., Prasad A., Sharkey S., Dote K., Akashi Y. J., Cammann V. L. и др. International Expert Consensus Document on Takotsubo Syndrome (Part I): Clinical Characteristics, Diagnostic Criteria, and Pathophysiology // European Heart Journal. https://oup.silverchair-cdn.com/article-minimal/5025412
Madaudo C., Kurdi H., Ielapi J. и др. The Role of Inflammation in Takotsubo Syndrome: From Pathogenic Pathways To Imaging Insights and Therapeutic Perspectives // Current Cardiology Reports. 2026. Vol. 28, No. 1. Art. 20. https://pmc.ncbi.nlm.nih.gov/articles/PMC12868080/
Chu B., Marwaha K., Sanvictores T., Awosika A. O., Ayers D. Physiology, Stress Reaction // StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2026 Jan-. https://www.ncbi.nlm.nih.gov/books/NBK541120/
Rezkalla S. H., Kloner R. A. Stress and Acute Coronary Syndrome // Cardiology Research. 2025. Vol. 16, No. 6. P. 467–474. https://pmc.ncbi.nlm.nih.gov/articles/PMC12758085/
Ebong I. A., Quesada O. и др.; American College of Cardiology Cardiovascular Disease in Women Committee. The Role of Psychosocial Stress on Cardiovascular Disease in Women: JACC State-of-the-Art Review // Journal of the American College of Cardiology. 2024. Vol. 84, No. 3. P. 298–314. https://pmc.ncbi.nlm.nih.gov/articles/PMC11328148/
Khalid N., Shams P., Shlofmitz E., Chhabra L. Pathophysiology of Takotsubo Syndrome // StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2026 Jan-. https://www.ncbi.nlm.nih.gov/books/NBK538160/
Kupper N., Denollet J. Type D Personality as a Risk Factor in Coronary Heart Disease: a Review of Current Evidence // Current Cardiology Reports. 2018. Vol. 20, No. 11. Art. 104. https://pmc.ncbi.nlm.nih.gov/articles/PMC6153564/
Carola V., Vincenzo C., Di Vincenzo G., Morale C., Cecchi V., Nicolais G. Psychological risk factors and cardiovascular disease // Frontiers in Psychology. 2024. Vol. 15. Art. 1419731. https://pubmed.ncbi.nlm.nih.gov/39403242/
Armon D. B., Buhayer A., Miteva K., Meinlschmidt G. и др. Depression and cardiovascular disease: mind the gap in the guidelines // European Heart Journal. 2025. Vol. 46, No. 41. P. 4226. https://pmc.ncbi.nlm.nih.gov/articles/PMC12579981/
Marino F., Failla C., Carrozza C., Ciminata M., Chilà P., Minutoli R., Genovese S., Puglisi A., Arnao A. A., Tartarisco G. и др. Mindfulness-Based Interventions for Physical and Psychological Wellbeing in Cardiovascular Diseases: A Systematic Review and Meta-Analysis // Brain Sciences. 2021. Vol. 11, No. 6. Art. 727. https://pmc.ncbi.nlm.nih.gov/articles/PMC8227381/
Rees K., Bennett P., West R., Davey Smith G., Ebrahim S. Psychological interventions for coronary heart disease // Cochrane Database of Systematic Reviews. 2004. No. 2. CD002902. https://pmc.ncbi.nlm.nih.gov/articles/PMC4170898/
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 Azamatjonov Akmaljon, Ganiyev Samandar Fazliddinovich, Khusanov Ravshan Akhrorovich, Baymuratova Dilfuza Kutlimuratovna, Khujakhonova Maftuna Tokhirovna
This work is licensed under a Creative Commons Attribution 4.0 International License.
