Acute Toxicity and Antitoxic Effect of Compositions of Cytisine N-Alkyl (Aryl) Derivatives with Succinic Acid

Authors

  • Latipova Shaxla Bekdurdiyevna Assistant of the Department of Pharmacology and Clinical Pharmacology, Urgench state medical university, Urgench, Uzbekistan
  • Azamatov Azizbek Azamat o‘g‘li PhD, Senior researcher at the Department of Pharmacology and Toxicology of the Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan
  • Tursunkhodzhaeva Firuza Muratovna DSc, professor, Head of the Department of Pharmacology and Toxicology of the Institute of Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan
  • Aytmuratova Urkhiya Kallibekovna PhD student, Department of Pharmacology and Toxicology, the Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan

Keywords:

Cytisine derivatives, succinic acid, antitoxic effect

Abstract

In the article, the acute toxicity, resorptive effects, and antitoxic activity of N-alkyl (aryl) derivatives of cytisine and their compositions with succinic acid were studied in experimental animals using models of alcohol- and hypnotic-induced intoxication. The results demonstrated that these compositions possess relatively low acute toxicity and exhibit antitoxic effects under conditions of narcotic intoxication by reducing the duration of sleep.

References

Zakusov V.V. Pharmacology of the central nervous system. - Moscow: Meditsina, 2004.

Lukyanova L.D. Antihypoxants: Achievements and Prospects. Moscow: Russian Academy of Medical Sciences, 2010.

Afanasyev V.V. Metabolic correctors in clinical practice. - St. Petersburg: SpetsLit, 2008.

Kulinsky V.I., Olkhovsky I.A. Succinate in the system of metabolic correction of hypoxic conditions // Experimental and clinical pharmacology. - 2011. - No. 4. - P. 3-8.

Mironov A.N. Guidelines for conducting preclinical studies of medicinal products. Part one. Moscow: Grif i K, 2012. - 944 p.

IBM SPSS Statistics 27 Documentation. https://www.ibm.com/support/pages/ibm-spss-statistics-27-documentation

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Published

2026-02-28

How to Cite

Latipova Shaxla Bekdurdiyevna, Azamatov Azizbek Azamat o‘g‘li, Tursunkhodzhaeva Firuza Muratovna, & Aytmuratova Urkhiya Kallibekovna. (2026). Acute Toxicity and Antitoxic Effect of Compositions of Cytisine N-Alkyl (Aryl) Derivatives with Succinic Acid. Emerging Frontiers Library for The American Journal of Medical Sciences and Pharmaceutical Research, 8(2), 207–210. Retrieved from https://emergingsociety.org/index.php/efltajmspr/article/view/1138

Issue

Vol. 8 No. 2 (2026)

Section

Articles

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Copyright (c) 2026 Latipova Shaxla Bekdurdiyevna, Azamatov Azizbek Azamat o‘g‘li, Tursunkhodzhaeva Firuza Muratovna, Aytmuratova Urkhiya Kallibekovna

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